The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management

Editors: J. Thomas Heywood; and John C. Burnett, Jr.
Foreword by Inder Anand MD

Published December 2011

Format: Hardcover; eBook

Trim size: 7 x 10 inches

ISBN: 9780979016479

256 pages, 80 illustrations/figures/tables

List price: $89.00  Sale price: $71.20

 
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"This book stands as a landmark in the study of the cardiorenal syndrome. It will no doubt be extremely useful to the cardiovascular specialist and internist caring for the growing number of these patients. And it will be just as useful to the scientists and the trainees interested in this condition."

- From the Foreword by Inder Anand, MD

 

Cardiorenal syndrome - the presence of significant renal insufficiency and heart failure simultaneously - constitutes one of the most vexing and difficult challenges facing clinicians and researchers today. Given the fundamental role of the kidneys in maintaining fluid and electrolyte balance within the body, it comes as no surprise that renal abnormalities are inextricably linked with congestive heart failure. What is surprising is that recent data have indicated that renal dysfunction is a more critical determinant of mortality than heart failure itself.

In The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management, experts from around the world clearly outline the current issues associated with this increasingly prevalent condition, provide invaluable insight into its pathophysiology, and highlight the risks, benefits, and rationales for both practical and promising prevention and treatment strategies, including:

  • Diuretics
  • Role of ACE inhibitors/ angiotensin receptor blockers in renal dysfunction
  • New "designer" peptides for heart failure
  • Inotropes and neurohormonal blockade
  • Dialysis and ultrafiltration
  • Renal cell therapy
  • Left ventricular assist device implantation
  • Renal and/or heart transplantation

While recognition of the role of renal dysfunction in the progression of heart failure is a pivotal advance, many questions about the scope and impact of this condition remain. This book serves as a touchstone for cardiovascular specialists and internists as they encounter the diverse varieties of cardiorenal syndrome and attempt to navigate the radically different and evolving therapeutic options in their quest to provide optimal individualized care for their patients.


Editors:

J. Thomas Heywood, MD; Director, Heart Failure Recovery & Research Program, Scripps Clinic, La Jolla, California; Clinical Professor of Medicine, Loma Linda University Medical Center, Loma Linda, California

John C. Burnett, Jr., MD, Marriott Family Professor of Cardiovascular Research, Mayo Clinic College of Medicine; Mayo Heart and Lung Research Center Director, Mayo Clinic, Rochester, Minnesota


Table of Contents:

Abbreviations
Foreword
Preface

1. The Role of the Kidney in Heart Failure
Robert W. Schrier, Shweta Bansal

2. The Role of Renal Nerves in Cardiorenal Syndrome in Heart Failure
Richard E. Katholi, Paul A. Sobotka, Henry Krum, Markus P. Schlaich

3. Diagnosis and Prognosis of Cardiorenal Syndrome
Maria Rosa Costanzo, Claudio Ronco

4. Epidemiology of Cardiorenal Syndrome
Kalkidan G. Bishu, Margaret M. Redfield

5. Hemodynamic Considerations in Cardiorenal Syndrome
W. H. Wilson Tang, Gary S. Francis

6. Diuretic Use in Heart Failure Patients with Renal Dysfunction
Jeremy S. Bock, Stephen S. Gottlieb

7. The Use of ACE Inhibitors and Angiotensin Receptor Blockers in Patients with Coexistent Renal Disease and Heart Failure
Domenic A. Sica

8. The Effect of Inotropes on Renal Function in Patients with Heart Failure
Tien M. H. Ng, Nudrat Khatri, and Uri Elkayam

9. Novel Chimeric Natriuretic Peptides and Cardiorenal Syndrome
Paul M. McKie, Fernando L. Martin, and John C. Burnett Jr.

10. New Therapies for Acute Heart Failure: Vasopressin Receptor Antagonists, Adenosine Receptor Antagonists
John Blair, Peter S. Pang, and Mihai Gheorghiade

11. Ultrafiltration for the Treatment of Heart Failure
Piergiuseppe Agostoni and Giancarlo Marenzi

12. Renal Cell Therapy: A Novel Approach to the Treatment of Cardiorenal Syndrome
Gretchen Hageman and H. David Humes

13. The Role of Renal Replacement Therapy and Transplantation in Patients with Cardiorenal Syndrome
Jigar Patel, Luis Alvarez, and Andrew King

14. Selection of Heart Failure Patients with Renal Dysfunction for Cardiac Transplantation
Tong Liu and Mariell Jessup

15. Mechanical Circulatory Support and Cardiorenal Syndrome
Brian E. Jaski and Mrunalini A. Joshi

16. Practical Management of Cardiorenal Syndrome: A Patient-Centered Approach
Tariq A. Khan and J. Thomas Heywood


Doody's Review Service 4-Star Rating:



Review from Circulation:

An up-to-date understanding of the underlying epidemiology, pathophysiology, and currently available treatments for patients with cardiorenal syndrome. This textbook is oriented toward the practicing internist or cardiologist who makes clinical decisions for patients experiencing cardiorenal syndrome.

The contributing authors include an impressive list of leading clinicians and researchers in the field of heart failure and cardiorenal syndrome. It is hard to imagine assembling a more distinguished and knowledgeable panel of contributors.

In summary, The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management is a wonderful, readable reference written by a panel of contributors unsurpassed in their expertise and experience dealing with the cardiorenal syndrome. It is ideally suited for the internist, cardiologist, or researcher with an interest in an up-to-date, well-referenced, clearly written guide to the cardiorenal syndrome. --Bradley Bart MD in Circulation.2012;126:e55