The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management

Edited by: J. Thomas Heywood, and John C. Burnett, Jr.
Foreword by Inder Anand MD

Product Details:
Published December 2011
ISBN: 9780979016479
Trim size: 7 x 10 inches
256 pages, 80 illustrations/figures/tables
Format: Hardcover; eBook

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"This book stands as a landmark in the study of the cardiorenal syndrome. It will no doubt be extremely useful to the cardiovascular specialist and internist caring for the growing number of these patients. And it will be just as useful to the scientists and the trainees interested in this condition."
- From the Foreword by Inder Anand, MD
 
Cardiorenal syndrome - the presence of significant renal insufficiency and heart failure simultaneously - constitutes one of the most vexing and difficult challenges facing clinicians and researchers today. Given the fundamental role of the kidneys in maintaining fluid and electrolyte balance within the body, it comes as no surprise that renal abnormalities are inextricably linked with congestive heart failure. What is surprising is that recent data have indicated that renal dysfunction is a more critical determinant of mortality than heart failure itself.

In The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management, experts from around the world clearly outline the current issues associated with this increasingly prevalent condition, provide invaluable insight into its pathophysiology, and highlight the risks, benefits, and rationales for both practical and promising prevention and treatment strategies, including:
    •    Diuretics
    •    Role of ACE inhibitors/ angiotensin receptor blockers in renal dysfunction
    •    New "designer" peptides for heart failure
    •    Inotropes and neurohormonal blockade
    •    Dialysis and ultrafiltration
    •    Renal cell therapy
    •    Left ventricular assist device implantation
    •    Renal and/or heart transplantation

While recognition of the role of renal dysfunction in the progression of heart failure is a pivotal advance, many questions about the scope and impact of this condition remain. This book serves as a touchstone for cardiovascular specialists and internists as they encounter the diverse varieties of cardiorenal syndrome and attempt to navigate the radically different and evolving therapeutic options in their quest to provide optimal individualized care for their patients.

Editors:

J. Thomas Heywood, MD; Director, Heart Failure Recovery & Research Program, Scripps Clinic, La Jolla, California; Clinical Professor of Medicine, Loma Linda University Medical Center, Loma Linda, California

John C. Burnett, Jr., MD, Marriott Family Professor of Cardiovascular Research, Mayo Clinic College of Medicine; Mayo Heart and Lung Research Center Director, Mayo Clinic, Rochester, Minnesota

Table of Contents:

Abbreviations
Foreword
Preface

1. The Role of the Kidney in Heart Failure
Robert W. Schrier, Shweta Bansal

2. The Role of Renal Nerves in Cardiorenal Syndrome in Heart Failure
Richard E. Katholi, Paul A. Sobotka, Henry Krum, Markus P. Schlaich

3. Diagnosis and Prognosis of Cardiorenal Syndrome
Maria Rosa Costanzo, Claudio Ronco

4. Epidemiology of Cardiorenal Syndrome
Kalkidan G. Bishu, Margaret M. Redfield

5. Hemodynamic Considerations in Cardiorenal Syndrome
W. H. Wilson Tang, Gary S. Francis

6. Diuretic Use in Heart Failure Patients with Renal Dysfunction
Jeremy S. Bock, Stephen S. Gottlieb

7. The Use of ACE Inhibitors and Angiotensin Receptor Blockers in Patients with Coexistent Renal Disease and Heart Failure
Domenic A. Sica

8. The Effect of Inotropes on Renal Function in Patients with Heart Failure
Tien M. H. Ng, Nudrat Khatri, and Uri Elkayam

9. Novel Chimeric Natriuretic Peptides and Cardiorenal Syndrome
Paul M. McKie, Fernando L. Martin, and John C. Burnett Jr.

10. New Therapies for Acute Heart Failure: Vasopressin Receptor Antagonists, Adenosine Receptor Antagonists
John Blair, Peter S. Pang, and Mihai Gheorghiade

11. Ultrafiltration for the Treatment of Heart Failure
Piergiuseppe Agostoni and Giancarlo Marenzi

12. Renal Cell Therapy: A Novel Approach to the Treatment of Cardiorenal Syndrome
Gretchen Hageman and H. David Humes

13. The Role of Renal Replacement Therapy and Transplantation in Patients with Cardiorenal Syndrome
Jigar Patel, Luis Alvarez, and Andrew King

14. Selection of Heart Failure Patients with Renal Dysfunction for Cardiac Transplantation
Tong Liu and Mariell Jessup

15. Mechanical Circulatory Support and Cardiorenal Syndrome
Brian E. Jaski and Mrunalini A. Joshi

16. Practical Management of Cardiorenal Syndrome: A Patient-Centered Approach
Tariq A. Khan and J. Thomas Heywood

Doody's Review Service 4-Star Rating:

Reviewer
Patrick Campbell,  MD(Ochsner Clinic Foundation)

Description
This is a succinct overview of the complex clinical interaction between the heart and kidneys in the setting of the failing heart. The editors brought together respected experts in the field of cardiorenal syndrome to produce a cohesive and comprehensive book.

Purpose
It is intended to further the understanding of the pathophysiology, diagnosis, and management of patients with the cardiorenal syndrome.

Audience
The authors present the information in a way that will be useful for clinicians of all levels, including medical students, interns, residents, midlevel practitioners, and practicing primary care and specialty clinicians.

Features
The book uses an easily accessible format with comprehensive chapters on pathophysiology, hemodynamics, pharmacology, nonpharmacological treatment strategies, and considerations in advanced heart failure patients.

Assessment
This is a well-written, concise, and thorough book. It is a timely addition to the growing knowledge base about a complex clinical problem that is challenging the healthcare system today.

Review from Circulation:

An up-to-date understanding of the underlying epidemiology, pathophysiology, and currently available treatments for patients with cardiorenal syndrome. This textbook is oriented toward the practicing internist or cardiologist who makes clinical decisions for patients experiencing cardiorenal syndrome.

The contributing authors include an impressive list of leading clinicians and researchers in the field of heart failure and cardiorenal syndrome. It is hard to imagine assembling a more distinguished and knowledgeable panel of contributors.

In summary, The Cardiorenal Syndrome: A Clinician's Guide to Pathophysiology and Management is a wonderful, readable reference written by a panel of contributors unsurpassed in their expertise and experience dealing with the cardiorenal syndrome. It is ideally suited for the internist, cardiologist, or researcher with an interest in an up-to-date, well-referenced, clearly written guide to the cardiorenal syndrome. --Bradley Bart MD in Circulation.2012;126:e55